反应详情

In a 500-ml flask, 100 g (0.95 mole) 4-methylthiosemicarbazide and 155 g [100 ml (1.36 mole)] trifluoroacetic acid were combined, refluxed 3 hours, and then allowed to stand overnight. Since the reaction mixture solidified overnight, it was heated to solution and then added to ice. The precipitated solid was filtered, washed with water and air-dried. The solid was dissolved in hot benzene and the water was separated. The benzene solution was concentrated cooled, and filtered to give the product as crystals.

1. temperaturerefluxed 3 hours
2. temperatureSince the reaction mixture solidified overnight, it was heated to solution
3. additionadded to ice
4. filtrationThe precipitated solid was filtered
5. washwashed with water
6. customair-dried
7. dissolutionThe solid was dissolved in hot benzene
8. customthe water was separated
9. concentrationThe benzene solution was concentrated
10. temperaturecooled
11. filtrationfiltered