3-Chloro-5-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one → 3-Phthalimido-5-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one

HRID 1632777Notes

Reaction equation

HRID 1632777 reaction equation
Cl[CH:2]1[C:8](=[O:9])[NH:7][C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[N:4]([CH3:14])[CH2:3]1.[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.[K]>O>[C:15]1(=[O:25])[N:19]([CH:2]2[C:8](=[O:9])[NH:7][C:6]3[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=3[N:4]([CH3:14])[CH2:3]2)[C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12

Participants

4

Reactant 2

HCID 204423493-Chloro-5-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneHCID 24194345Phthalimide potassium salt

Product 1

HCID 204423203-Phthalimido-5-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.05 g of 3-chloro-5-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one and 1.0 of potassium phthalimide is warmed to 90° overnight. The reaction mixture is poured into 20 ml of water and stirring is continued for 1 hr. Isolation and drying affords 3-phthalimido-5-methyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one.

Workup

  1. temperatureis warmed to 90° overnight
  2. customIsolation and drying

Sources & evidence

ORD record
ord-6b6b42fb61674159b044280a4ef6aaf7
Source dataset
uspto-grants-1984_10
Patent number
US04477464

Reaction notes

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