2-Methylindole → HCID 54539353, compound

HRID 1632893Notes

Reaction equation

HRID 1632893 reaction equation
[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH3:15])=[CH:11][CH:12]=2)[C:7]([C:16](=[O:24])[C:17]([Cl:23])=[C:18]([Cl:22])[C:19]([OH:21])=O)=[CH:6]1)[CH2:2][CH2:3][CH3:4].[Cl:25][C:26]1[CH:27]=[C:28]([CH:41]=[CH:42][CH:43]=1)[CH2:29][N:30]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]=[C:31]1[CH2:39][CH3:40].CC1NC2C(C=1)=CC=CC=2>>[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH3:15])=[CH:11][CH:12]=2)[C:7]([C:16]2([C:32]3[C:33]4[C:38](=[CH:37][CH:36]=[CH:35][CH:34]=4)[N:30]([CH2:29][C:28]4[CH:41]=[CH:42][CH:43]=[C:26]([Cl:25])[CH:27]=4)[C:31]=3[CH2:39][CH3:40])[O:24][C:19](=[O:21])[C:18]([Cl:22])=[C:17]2[Cl:23])=[CH:6]1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 72242-MethylindoleHCID 19869964HCID 19869964, compoundHCID 54127367HCID 54127367, compound

Product 1

HCID 54539353HCID 54539353, compound

Procedure

Following a procedure similar to that described above in part B of this example by using 4-(1-n-butyl-5-methoxy-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid instead of 4-(1-ethyl-2-methyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid and 1-(3-chlorobenzyl)-2-ethylindole is substituted for 2-methyl-indole, there is obtained 5-(1-n-butyl-5-methoxy-3-indolyl)-5-[1-(3-chlorobenzyl)-2-ethyl-3-indolyl]-3,4-dichloro-2(5H)-furanone (Formula V: R=CH3 (CH2)2CH2 ; R1 =Y1 =H; R2 =3-ClC6H4CH2 ; R3 =CH3CH2 ; Y=5-CH3O).

Sources & evidence

ORD record
ord-03b8e1a8dc98419a9cc2f7a956b7f4fb
Source dataset
uspto-grants-1984_10
Patent number
US04477676

Reaction notes

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