1-Butanol → n-Butylphosphorodichloridate

HRID 1632939Notes

Reaction equation

HRID 1632939 reaction equation
[P:1](Cl)([Cl:4])([Cl:3])=[O:2].[CH2:6]([OH:10])[CH2:7][CH2:8][CH3:9]>C(Cl)(Cl)(Cl)Cl>[P:1]([Cl:4])([Cl:3])([O:10][CH2:6][CH2:7][CH2:8][CH3:9])=[O:2]

Participants

4

Reactant 2

HCID 2631-ButanolHCID 24813Phosphorus oxychloride

Product 1

HCID 137039n-Butylphosphorodichloridate

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

To phosphoryl chloride (50 ml) in 40 ml of carbon tetrachloride at ambient temperature was added dropwise n-butanol (29.65 g). After the initial exothermic reaction subsided, the reaction mixture was refluxed for 3 hours. Vacuum distillation at 88°-103° C. yielded 59.114 g of n-butyl dichlorophosphate.

Workup

  1. customAfter the initial exothermic reaction
  2. temperaturethe reaction mixture was refluxed for 3 hours
  3. distillationVacuum distillation at 88°-103° C.

Sources & evidence

ORD record
ord-b6a98516fdf34bc596b18b60c4e03b1c
Source dataset
uspto-grants-1984_10
Patent number
US04478749

Reaction notes

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