Nitrous Acid → 5-Nitroso-8-hydroxyisoquinoline
Reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[N:9][CH:8]=[CH:7]2.[N:12](O)=[O:13]>>[N:12]([C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[C:11]2[C:6]=1[CH:7]=[CH:8][N:9]=[CH:10]2)=[O:13]Participants
3
Procedure
The 8-hydroxyisoquinoline is reacted with nitrous acid to form 5-nitroso-8-hydroxyisoquinoline. The nitrous acid is generated in situ by the action of mineral acid, such as hydrochloric, sulfuric, and the like, on sodium nitrite usually under cold temperature conditions.
Sources & evidence
- ORD record
- ord-00cfb305baf9440db3a2eac8175ef501
- Source dataset
- uspto-grants-1984_10
- Patent number
- US04478820
Reaction notes
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