HCID 13374598, compound → HCID 13374600, compound

HRID 1632956Notes

Reaction equation

HRID 1632956 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:13]([C:14](OCC)=[O:15])=[C:12]([CH3:19])[NH:11][C:10]([CH3:20])=[C:9]1[C:21]([O:23][CH2:24][CH3:25])=[O:22]>CN(C=O)C>[CH2:24]([O:23][C:21]([C:9]1[CH:8]2[C:13](=[C:12]([CH3:19])[NH:11][C:10]=1[CH3:20])[C:14](=[O:15])[NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]2=1)=[O:22])[CH3:25]

Participants

3

Reactant 1

HCID 13374598HCID 13374598, compound

Product 1

HCID 13374600HCID 13374600, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Diethyl 1,4-dihydro-4-(2-aminophenyl)-2,6-dimethyl-3,5-pyridine dicarboxylate (90.0 gms., 0.26 mole) was dissolved in 250 ml dry DMF and the solution refluxed for a period of 72 hours. The solvent was removed under vacuum and the residue recrystallized twice from ethyl acetate to afford 5.4 gms (7%), m.p. 236°-238° C.

Workup

  1. temperaturethe solution refluxed for a period of 72 hours
  2. customThe solvent was removed under vacuum
  3. customthe residue recrystallized twice from ethyl acetate
  4. customto afford 5.4 gms (7%), m.p. 236°-238° C.

Sources & evidence

ORD record
ord-f5a3145c3c4c48a0bc44b5671486c586
Source dataset
uspto-grants-1984_10
Patent number
US04478834

Reaction notes

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