HCID 13205992, compound → HCID 13205991, compound

HRID 1632978Notes

Reaction equation

HRID 1632978 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:18])[CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)=[CH:3][CH:2]=1>C(O)(=O)C.[Pt]=O>[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]([CH3:18])[CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 13205992HCID 13205992, compound

Product 1

HCID 13205991HCID 13205991, compoundYield 30.5%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

0.8 g of 3-[2-(4-pyridyl)-2-methyl-ethyl]-indole were hydrogenated at atmospheric pressure for a period of 15 hours at 60° C. in 20 ml acetic acid in the presence of 0.4 g platinum oxide. The catalyst was eliminated by filtration and the filtrate evaporated. The residue was purified by chromatography over silica (eluant: ethanol-diethylamine: 9-1). 0.25 g 3-[2-(4-piperidyl)-2-methyl-ethyl]-indole were obtained which were converted into the hydrochloride in ethanol. 0.15 g 3-[2-(4-piperidyl)-2-methyl-ethyl]-indole hydrochloride were obtained, which melted at 210° C.

Workup

  1. filtrationThe catalyst was eliminated by filtration
  2. customthe filtrate evaporated
  3. customThe residue was purified by chromatography over silica (eluant: ethanol-diethylamine: 9-1)

Sources & evidence

ORD record
ord-0f62529796954a9e8ac34a2e3424492e
Source dataset
uspto-grants-1984_10
Patent number
US04478841

Reaction notes

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