HCID 13205992, compound → HCID 13205991, compound

Participants

Reaction Steps

0.8 g of 3-[2-(4-pyridyl)-2-methyl-ethyl]-indole were hydrogenated at atmospheric pressure for a period of 15 hours at 60° C. in 20 ml acetic acid in the presence of 0.4 g platinum oxide. The catalyst was eliminated by filtration and the filtrate evaporated. The residue was purified by chromatography over silica (eluant: ethanol-diethylamine: 9-1). 0.25 g 3-[2-(4-piperidyl)-2-methyl-ethyl]-indole were obtained which were converted into the hydrochloride in ethanol. 0.15 g 3-[2-(4-piperidyl)-2-methyl-ethyl]-indole hydrochloride were obtained, which melted at 210° C.

Provenance & Evidence