Hydrazine hydrate (1:1) → HCID 12582683, compound

HRID 1633043Notes

Reaction equation

HRID 1633043 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:25])[C:13]3[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[CH:14]=3)[CH2:11][C:4]=2[CH:3]=1.O.[NH2:27][NH2:28]>O1CCOCC1>[NH:27]([C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=[O:25])[C:13]3[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[CH:14]=3)[CH2:11][C:4]=2[CH:3]=1)[NH2:28]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20441562HCID 20441562, compound

Product 1

HCID 12582683HCID 12582683, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

12.8 g of 3-chloro-5,6,7,8-tetrahydro-6-(3,4,5-trimethoxybenzoyl)pyrido[4,3-c]pyridazine and 40 cc of hydrazine hydrate in 40 cc of dioxane are stirred at a bath temperature of 100° for 41/2 hours. The title compound has a M.P. of 194°-197° (decomp., from absolute ethanol/methanol 2:1).

Sources & evidence

ORD record
ord-919ebe0d4c8f491292ed17089b391497
Source dataset
uspto-grants-1984_10
Patent number
US04478837

Reaction notes

Loading…