Hydrazine hydrate (1:1) → HCID 20441589, compound

HRID 1633066Notes

Reaction equation

HRID 1633066 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([C:12](=O)[C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:15][CH:14]=3)[CH2:11][C:4]=2[CH:3]=1.O.[NH2:27][NH2:28]>>[NH:27]([C:2]1[N:7]=[N:6][C:5]2[CH2:8][CH2:9][N:10]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:15][CH:14]=3)[CH2:11][C:4]=2[CH:3]=1)[NH2:28]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20441550HCID 20441550, compound

Product 1

HCID 20441589HCID 20441589, compound

Procedure

9.0 g of 3-chloro-6-(p-phenylbenzoyl)-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine and 55 cc of hydrazine hydrate and stirred at a bath temperature of 100° for 51/2 hours. After cooling the mixture with ice the title compound precipitates and is recrystallized from 200 cc of dimethyl formamide. M.P. 241°-244° (decomp.).

Sources & evidence

ORD record
ord-9de735754c8947cbafebef481483ba74
Source dataset
uspto-grants-1984_10
Patent number
US04478837

Reaction notes

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