Potassium Iodide → Methyl 4-(2-oxopropoxy)benzoate

HRID 1633101노트

반응식

HRID 1633101 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.Cl[CH2:13][C:14](=[O:16])[CH3:15].[I-].[K+]>CC(C)=O>[C:6]([C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:13][C:14](=[O:16])[CH3:15])=[CH:11][CH:10]=1)([O:8][CH3:9])=[O:7]

참가 물질

5

반응물 3

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 7456Methylparaben

생성물 1

HCID 21832186Methyl 4-(2-oxopropoxy)benzoate수율 188.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of methyl 4-hydroxybenzoate (30.4 g), chloroacetone (8.5 g) potassium carbonate (54 g) and potassium iodide (33.3 g) was refluxed in acetone for 4 hours. The reaction mixture was cooled, the solids filtered and the solvent evaporated. The residue was partitioned between water and ether, the layers separated and the organic layer dried (MgSO4). Removal of the solvent gave the title compound (36 g). τ (CDCl3) 7.75 (3H, s), 6.11 (3H, s) 5.39 (2H, s), 3.09 (2H, d, J=9 Hz), 2.0 (2H, d, J=9 Hz).

후처리

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe solids filtered
  3. customthe solvent evaporated
  4. customThe residue was partitioned between water and ether
  5. customthe layers separated
  6. dry with materialthe organic layer dried (MgSO4)
  7. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-a7c5a8d3f7c24e23863ee5d2a8d4dd0a
출처 데이터셋
uspto-grants-1984_10
특허 번호
US04478849

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