反应详情

A mixture of methyl 4-hydroxybenzoate (30.4 g), chloroacetone (8.5 g) potassium carbonate (54 g) and potassium iodide (33.3 g) was refluxed in acetone for 4 hours. The reaction mixture was cooled, the solids filtered and the solvent evaporated. The residue was partitioned between water and ether, the layers separated and the organic layer dried (MgSO4). Removal of the solvent gave the title compound (36 g). τ (CDCl3) 7.75 (3H, s), 6.11 (3H, s) 5.39 (2H, s), 3.09 (2H, d, J=9 Hz), 2.0 (2H, d, J=9 Hz).

1. temperatureThe reaction mixture was cooled
2. filtrationthe solids filtered
3. customthe solvent evaporated
4. customThe residue was partitioned between water and ether
5. customthe layers separated
6. dry with materialthe organic layer dried (MgSO4)
7. customRemoval of the solvent