反应详情

A mixture of 4.7 g of 1-[2-(4-ethoxycarbonylphenoxy)ethyl]-2-(3-pyridyl)-3-methylindole in 220 ml of 2N hydrochloric acid is heated under reflux for 6 hours. After cooling the solution is made basic with 3 N NaOH and extracted with ethyl acetate. The basic solution is filtered and acidified to pH 6-7 with 5 N HCl. The solid is collected, dried and recrystallized from acetone to give 1-[2-(4-carboxyphenoxy)ethyl]-2-(3-pyridyl)-3-methylindole, m.p. 190°-193°.

1. temperatureis heated
2. temperatureunder reflux for 6 hours
3. temperatureAfter cooling the solution
4. extractionextracted with ethyl acetate
5. filtrationThe basic solution is filtered
6. customThe solid is collected
7. customdried
8. customrecrystallized from acetone