Amyl Acetate → Amyl 3-Hydroxy-3-methyl-3-(4-pyridyl)propionate

HRID 1633168Notes

Reaction equation

[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])(=[O:3])[CH3:2].[C:10]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)(=[O:12])[CH3:11]>>[OH:12][C:10]([CH3:11])([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[CH2:2][C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])=[O:3]

Participants

Reactant 2

HCID 12348Amyl Acetate

HCID 142824-Acetylpyridine

Product 1

HCID 20441861Amyl 3-Hydroxy-3-methyl-3-(4-pyridyl)propionate

Procedure

A 100 milligram quantity of the hydroxy ester described in Example III is pyrolyzed in a sealed tube at 400° C. for 3 minutes. Analysis of the pyrolysis mixture by gas chromatography indicates the presence of about 30% of a mixture in a 1:1 ratio of amyl acetate and 4-acetylpyridine. The remainder of the mixture contains unreacted starting material.

Sources & evidence

ORD record: ord-b8cf7ffe2be042bf88db1317917a3329
Source dataset: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04479003

Reaction notes

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