HCID 20440425, compound → HCID 20440412, compound

HRID 1633263Notes

Reaction equation

HRID 1633263 reaction equation
O1CCCCC1[N:7]1[C:15]2[C:10](=[C:11]([O:16][CH2:17][CH:18]([OH:31])[CH2:19][NH:20][CH2:21][CH2:22][NH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])[CH:12]=[CH:13][CH:14]=2)[CH:9]=[N:8]1>C(O)C>[NH:7]1[C:15]2[C:10](=[C:11]([O:16][CH2:17][CH:18]([OH:31])[CH2:19][NH:20][CH2:21][CH2:22][NH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])[CH:12]=[CH:13][CH:14]=2)[CH:9]=[N:8]1

Participants

3

Reactant 1

HCID 20440425HCID 20440425, compound

Product 1

HCID 20440412HCID 20440412, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
25 °C

Procedure

7.8 g. (175 mmol) 1-[1-(Tetrahydropyran-2-yl)-indazol-4-yloxy]-3-[2-(2-chlorophenylamino)-ethylamino]-propan-2-ol in 250 ml. ethanol are mixed with the ion exchanger "Amberlite" CG 120 II (H+ form) and then stirred for 24 hours at 25° C. The ion exchanger is separated off and thoroughly washed with 2% ammonia in methanol. The combined solutions are evaporated and the residue obtained is recrystallized from ethyl acetate. There are obtained 3.6 g. (57% of theory) of the desired compound; m.p. 129°-130° C.

Workup

  1. customThe ion exchanger is separated off
  2. washthoroughly washed with 2% ammonia in methanol
  3. customThe combined solutions are evaporated
  4. customthe residue obtained
  5. customis recrystallized from ethyl acetate
  6. customThere are obtained 3.6 g

Sources & evidence

ORD record
ord-6ad903263afe4f5c87586bcec900703a
Source dataset
uspto-grants-1984_10
Patent number
US04479962

Reaction notes

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