HCID 20440425, compound → HCID 20440412, compound

Participants

Reaction Conditions

Reaction Steps

7.8 g. (175 mmol) 1-[1-(Tetrahydropyran-2-yl)-indazol-4-yloxy]-3-[2-(2-chlorophenylamino)-ethylamino]-propan-2-ol in 250 ml. ethanol are mixed with the ion exchanger "Amberlite" CG 120 II (H+ form) and then stirred for 24 hours at 25° C. The ion exchanger is separated off and thoroughly washed with 2% ammonia in methanol. The combined solutions are evaporated and the residue obtained is recrystallized from ethyl acetate. There are obtained 3.6 g. (57% of theory) of the desired compound; m.p. 129°-130° C.

Provenance & Evidence