HRID1633313

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1N

HCID54526695

未命名化合物

结构：COC(=O)COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1

HCID59910020

未命名化合物

PRODUCTS

生成物

结构：COC(=O)COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N)ncnc43)O[C@@H]2C(=O)OC)cc1

HCID70465257

未命名化合物

收率 23.7%

PROCEDURE

实验过程

Methyl 1-(6-amino-9H-purin-9-yl)-3-[N-tert-butoxycarbonyl-O-methoxycarbonylmethyl-L-tyrosylamino]-1,3-dideoxy-β-D-ribofuranuronate (220 mg) was prepared by reacting methyl 1-(6-amino-9H-purin-9-yl)-3-amino-1,3-dideoxy-β-D-ribofuranuronate (577 mg) prepared in Example 62 with N-tert-butoxycarbonyl-O-methoxycarbonylmethyl-L-tyrosine (520 mg) prepared in Preparation 8 (2) according to a similar manner to that of Example 64, mp. 115°-120° (dec.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0e0e32a6f97b4ee09519a57b2fbf6372
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04479942
来源说明: uspto-grants-1984_10

反应 SMILES

[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([O:19][CH3:20])=[O:18])[C@@H:14]([NH2:21])[C@H:12]1[OH:13].[C:22]([O:26][C:27]([NH:29][C@H:30]([C:44](O)=[O:45])[CH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][CH2:39][C:40]([O:42][CH3:43])=[O:41])=[CH:34][CH:33]=1)=[O:28])([CH3:25])([CH3:24])[CH3:23]>>[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([O:19][CH3:20])=[O:18])[C@@H:14]([NH:21][C:44](=[O:45])[C@H:30]([CH2:31][C:32]2[CH:33]=[CH:34][C:35]([O:38][CH2:39][C:40]([O:42][CH3:43])=[O:41])=[CH:36][CH:37]=2)[NH:29][C:27]([O:26][C:22]([CH3:24])([CH3:25])[CH3:23])=[O:28])[C@H:12]1[OH:13]