HRID1633317

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cc1

HCID2762280

Boc-O-methyl-L-tyrosine

C15H21NO5

结构：COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N)ncnc43)O[C@@H]2C(=O)O)cc1.Cl.Cl.O

HCID70466244

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N)ncnc43)O[C@@H]2C(=O)O)cc1

HCID70465461

未命名化合物

收率 28.3%

PROCEDURE

实验过程

1-(6-Amino-9H-purin-9-yl)-3-[N-(N-tert-butoxycarbonyl-O-methyl-L-tyrosyl)-O-methyl-L-tyrosylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (125 mg) was prepared by reacting 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-(O-methyl-L-tyrosylamino)-β-D-ribofuranuronic acid dihydrochloride monohydrate (330 mg) prepared in Example 4 with N-hydroxysuccinimide ester of N-tert-butoxycarbonyl-O-methyl-L-tyrosine (255 mg) according to a similar manner to that of Example 5, mp. 178°-180° C. (dec.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f1ad1e6853d945988ab7953886c912fc
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04479942
来源说明: uspto-grants-1984_10

反应 SMILES

O.Cl.Cl.[NH2:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[C@@H:14]1[O:19][C@H:18]([C:20]([OH:22])=[O:21])[C@@H:17]([NH:23][C:24](=[O:36])[C@H:25]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[NH2:26])[C@H:15]1[OH:16].[C:37]([O:41][C:42]([NH:44][C@H:45]([C:55](O)=[O:56])[CH2:46][C:47]1[CH:52]=[CH:51][C:50]([O:53][CH3:54])=[CH:49][CH:48]=1)=[O:43])([CH3:40])([CH3:39])[CH3:38]>>[NH2:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[C@@H:14]1[O:19][C@H:18]([C:20]([OH:22])=[O:21])[C@@H:17]([NH:23][C:24](=[O:36])[C@H:25]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[NH:26][C:55](=[O:56])[C@H:45]([CH2:46][C:47]2[CH:48]=[CH:49][C:50]([O:53][CH3:54])=[CH:51][CH:52]=2)[NH:44][C:42]([O:41][C:37]([CH3:39])([CH3:40])[CH3:38])=[O:43])[C@H:15]1[OH:16]