HCID 70465461, compound → 3-{2-[2-Amino-3-(4-methoxyphenyl)propanoylamino]-3-(4-methoxyphenyl)propanoylamino}-5-(6-aminopurin-9-yl)-4-hydroxyoxolane-2-carboxylic acid

HRID 1633318Notes

Reaction equation

HRID 1633318 reaction equation
[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([OH:19])=[O:18])[C@@H:14]([NH:20][C:21](=[O:53])[C@H:22]([CH2:44][C:45]2[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[CH:47][CH:46]=2)[NH:23][C:24](=[O:43])[C@H:25]([CH2:34][C:35]2[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=2)[NH:26]C(OC(C)(C)C)=O)[C@H:12]1[OH:13]>C(O)=O>[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([OH:19])=[O:18])[C@@H:14]([NH:20][C:21](=[O:53])[C@H:22]([CH2:44][C:45]2[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[CH:47][CH:46]=2)[NH:23][C:24](=[O:43])[C@H:25]([CH2:34][C:35]2[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=2)[NH2:26])[C@H:12]1[OH:13]

Participants

3

Reactant 1

HCID 70465461HCID 70465461, compound

Product 1

HCID 4761383-{2-[2-Amino-3-(4-methoxyphenyl)propanoylamino]-3-(4-methoxyphenyl)propanoylamino}-5-(6-aminopurin-9-yl)-4-hydroxyoxolane-2-carboxylic acidYield 53.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

1-(6-Amino-9H-purin-9-yl)-3-[N-(O-methyl-L-tyrosyl)-O-methyl-L-tyrosylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (46 mg) was prepared by reacting 1-(6-amino-9H-purin-9-yl)-3-[N-(N-tert-butoxycarbonyl-O-methyl-L-tyrosyl)-O-methyl-L-tyrosylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (100 mg) prepared in Example 86 with formic acid according to a similar manner to that of Example 45, mp. 175°-177° C. (dec.).

Sources & evidence

ORD record
ord-b0663176680d424e9eb6deee976e9569
Source dataset
uspto-grants-1984_10
Patent number
US04479942

Reaction notes

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