反应详情

To 150 ml of an anhydrous ether solution of methyl magnesium iodide prepared from 3.23 g of magnesium metal and 19.0 g of methyl iodide, with ice-cooling, was added dropwise a solution of 8.32 g of methyl 2-allyl-5-chloroindane-2-carboxylate in 10 ml of anhydrous ether. The mixture was stirred for 24 hours at room temperature to complete the reaction. The reaction mixture was poured into a mixture of saturated aqueous ammonium chloride solution and ice. After the ether layer was separated, the aqueous layer was extracted twice with ether. The ether layers were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain 7.56 g of the intended product.

1. temperaturecooling
2. customthe reaction
3. customAfter the ether layer was separated
4. extractionthe aqueous layer was extracted twice with ether
5. washwashed with saturated sodium chloride solution
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated in vacuo