Water → HCID 86758768, compound

HRID 1633475Notes

Reaction equation

HRID 1633475 reaction equation
[C:1]([O-:4])(=[S:3])[CH3:2].[K+].[CH2:6]([O:8][C:9]([C:11]1([CH2:21]Br)[CH2:20][CH2:19][C:14]2([O:18][CH2:17][CH2:16][O:15]2)[CH2:13][CH2:12]1)=[O:10])[CH3:7].O>CN(C=O)C>[CH2:6]([O:8][C:9]([C:11]1([CH2:21][S:3][C:1](=[O:4])[CH3:2])[CH2:20][CH2:19][C:14]2([O:15][CH2:16][CH2:17][O:18]2)[CH2:13][CH2:12]1)=[O:10])[CH3:7]

Participants

5

Reactant 3

HCID 962WaterHCID 5163850HCID 5163850, compoundHCID 23670855Potassium ethanethioate

Product 1

HCID 86758768HCID 86758768, compoundYield 101.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Potassium thioacetate (1.0 g) was added to a solution of 8-bromomethyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester (1.0 g) in DMF (30 ml) and the solution was heated at 80° C. for 4 h. The mixture was then added to water (100 ml) and extracted with ether. The solvent was washed with water, bicarbonate solution and brine, then dried (MgSO4) and evaporated to give the title compound (1.0 g) as colourless oil.

Workup

  1. extractionextracted with ether
  2. washThe solvent was washed with water, bicarbonate solution and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-b17175742bef4de68f61de50a623950d
Source dataset
uspto-grants-2003_01
Patent number
US06503910B1

Reaction notes

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