Hydrochloric Acid → HCID 390904, compound

HRID 1633567Notes

Reaction equation

HRID 1633567 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=O)[CH2:8][CH2:7][CH2:6]2.Cl.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23]N)=[CH:19][CH:18]=1.Cl.O>C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:9]3[NH:23][C:20]4[C:21]([C:8]=3[CH2:7][CH2:6][C:5]=2[CH:4]=1)=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=4

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 141126-Methoxy-alpha-tetraloneHCID 27239044-Methoxyphenylhydrazine hydrochloride

Product 1

HCID 390904HCID 390904, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

10.0 g (57 mmol) of 6-methoxy-1-tetralone in 125 ml of ethanol is added in drops within 35 minutes to a boiling solution of 10.0 g (57 mmol) of p-methoxyphenylhydrazine-hydrochloride and 5.0 ml of concentrated hydrochloric acid in 180 ml of ethanol. Then, it is refluxed for 5 hours. After 370 ml of hot water is added, it is allowed to cool. The almost colorless reaction product is suctioned off and recrystallized from ethanol. Yield 74%, melting point 189-191° C.

Workup

  1. temperatureThen, it is refluxed for 5 hours
  2. temperatureto cool
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-d7a0f3ccc7474683b10f8345ae8bfd3c
Source dataset
uspto-grants-2003_01
Patent number
US06503938B1

Reaction notes

Loading…