Piperidine → 1-(4-Fluoro-phenyl)-5-(7-piperidin-1-yl-heptyloxy)-1H-indole

HRID 1633619Notes

Reaction equation

HRID 1633619 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[N:15]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)[CH:14]=[CH:13]2.[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:25][C:22]1[CH:23]=[CH:24][C:19]([N:15]2[C:16]3[C:12](=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)=[CH:18][CH:17]=3)[CH:13]=[CH:14]2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 186795565-(7-Bromo-heptyloxy)-1-(4-fluoro-phenyl)-1H-indole

Product 1

HCID 186794521-(4-Fluoro-phenyl)-5-(7-piperidin-1-yl-heptyloxy)-1H-indole

Procedure

In analogy to example 2.2, 5-(7-Bromo-heptyloxy)-1-(4-fluoro-phenyl)-1H-indole and piperidine were converted to yield 1-(4-Fluoro-phenyl)-5-(7-piperidin-1-yl-heptyloxy)-1H-indole as colorless gum, MS: 408 (MH+).

Sources & evidence

ORD record
ord-b8842bfbe76544328190c8081e1da245
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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