2-(Ethylamino)ethanol → 2-(Ethyl-{4-[1-(4-fluoro-phenyl)-1H-indol-5-yloxy]-but-2-enyl}-amino)-ethanol

HRID 1633625Notes

Reaction equation

HRID 1633625 reaction equation
Br[CH2:2][CH:3]=[CH:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[CH:11]=[CH:10]2.[CH2:23]([NH:25][CH2:26][CH2:27][OH:28])[CH3:24]>>[CH2:23]([N:25]([CH2:2][CH:3]=[CH:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[CH:11]=[CH:10]2)[CH2:26][CH2:27][OH:28])[CH3:24]

Participants

3

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 695480995-(4-Bromo-but-2-enyloxy)-1-(4-fluoro-phenyl)-1H-indole

Product 1

HCID 695478482-(Ethyl-{4-[1-(4-fluoro-phenyl)-1H-indol-5-yloxy]-but-2-enyl}-amino)-ethanol

Procedure

In analogy to example 3.3, 5-(4-Bromo-but-2-enyloxy)-1-(4-fluoro-phenyl)-1H-indole and 2-ethylaminoethanol were converted to yield 2-(Ethyl-{4-[1-(4-fluoro-phenyl)-1H-indol-5-yloxy]-but-2-enyl}-amino)-ethanol as colorless viscous oil, MS: 369 (MH+).

Sources & evidence

ORD record
ord-09c491add7184adca9ce38499ff18038
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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