Propargyl alcohol → 3-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-prop-2-yn-1-ol

HRID 1633635Notes

Reaction equation

HRID 1633635 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13](OS(C(F)(F)F)(=O)=O)=[CH:14][CH:15]=3)[CH:10]=[CH:9]2)=[CH:4][CH:3]=1.[CH2:25]([OH:28])[C:26]#[CH:27]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([C:27]#[C:26][CH2:25][OH:28])=[CH:14][CH:15]=3)[CH:10]=[CH:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7859Propargyl alcoholHCID 86585583Trifluoro-methanesulfonic acid 1-(4-fluoro-phenyl)-1H-indol-5-yl ester

Product 1

HCID 186794723-[1-(4-Fluoro-phenyl)-1H-indol-5-yl]-prop-2-yn-1-ol

Procedure

In analogy to example 5.2, Trifluoro-methanesulfonic acid 1-(4-fluoro-phenyl)-1H-indol -5-yl ester and propargylalcohol were converted to yield 3-[1-(4-Fluoro-phenyl)-1H-indol -5-yl]-prop-2-yn-1-ol as light brown solid, 85-88° C., MS: 265 (M).

Sources & evidence

ORD record
ord-8cc8e9a76151448b969b4eb5f7180c45
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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