1-Bromo-4-fluorobenzene → HCID 18679567, compound

HRID 1633651Notes

Reaction equation

HRID 1633651 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:18][C:19]1[CH:24]=[CH:23][C:22](F)=[CH:21][CH:20]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([C:22]1[CH:23]=[CH:24][C:19]([Br:18])=[CH:20][CH:21]=1)[CH:13]=[CH:12]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 99931-Bromo-4-fluorobenzeneHCID 146245-Benzyloxyindole

Product 1

HCID 18679567HCID 18679567, compound

Procedure

In analogy to example 4.6, 5-benzyloxy-indole and and 1-bromo-4-fluoro-benzene were converted to yield 5-Benzyloxy-1-(4-bromo-phenyl)-1H-indole as light brown solid, mp 118° C., MS: 377 (M, 1Br).

Sources & evidence

ORD record
ord-a2f2fc23b1634b87b161a1535f6bc5af
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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