HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic acid 5-[1-(4-bromo-phenyl)-1H-indol-5-yl]-pent-4-ynyl ester → Methanesulfonic acid 5-[1-(4-bromo-phenyl)-1H-indol-5-yl]-pentyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic acid 5-[1-(4-bromo-phenyl)-1H-indol-5-yl]-pent-4-ynyl ester | HCID 86585589 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | EtOAc EtOH hexane | HCID 21875506 | — |
| Product | Methanesulfonic acid 5-[1-(4-bromo-phenyl)-1H-indol-5-yl]-pentyl ester | HCID 86585590 | 95% |
Reaction Steps
432 mg (1 mmol) Methanesulfonic acid 5-[1-(4-bromo-phenyl)-1H-indol-5-yl]-pent-4-ynyl ester in 30 ml EtOAc/EtOH/hexane (1:1:1) was hydrogenated in the presence of 20 mg PtO2, the solution was filtered and evaporated. Column chromatography on silica gel with hexane/EtOAc 4:1 yielded (95%) Methanesulfonic acid 5-[1-(4-bromo-phenyl)-1H-indol-5-yl]-pentyl ester as colorless viscous oil, MS: 435 (M, 1Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503907B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-121b0ce93cc848b6992e73bb9df64544 |
| Source note | uspto-grants-2003_01 |