反应详情

970 mg (2.6 mmol) 5-[1-(4-Trimethylsilanylethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol in 10 ml MeOH were treated with 41.4 mg (3 mmol) K2CO3. The solution was concentrated, the residue dissolved in ether and 0.5M HCl and the organic phase was washed with water and dried over Na2SO4. Column chromatography on silica gel with ether yielded 680 mg (87%) 5-[1-(4-Ethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol as orange oil, MS: 299 (M).

1. concentrationThe solution was concentrated
2. dissolutionthe residue dissolved in ether
3. wash0.5M HCl and the organic phase was washed with water
4. dry with materialdried over Na2SO4