HCID 18679551, compound → HCID 18679515, compound

HRID 1633669Notes

Reaction equation

HRID 1633669 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]#[C:19][CH2:20][CH2:21][CH2:22][N:23]([CH3:27])[CH2:24][CH2:25][OH:26])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][CH:4]=1)#[CH:2]>O=[Pt]=O>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][N:23]([CH3:27])[CH2:24][CH2:25][OH:26])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 1

HCID 18679551HCID 18679551, compound

Product 1

HCID 18679515HCID 18679515, compound

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

In analogy to example 10.8 (PtO2 was used instead of Pd/C), 2-({5-[1-(4-Ethynyl-phenyl)-1H-indol-5-yl]-pent-4-ynyl}-methyl-amino)-ethanol was converted to yield 2-({5-[1-(4-Ethyl-phenyl)-1H-indol-5-yl]-pentyl}-methyl-amino)-ethanol as colorless oil, MS: 365 (MH+).

Sources & evidence

ORD record
ord-39cdb7d2831f482c831ce653f17ef7dd
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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