1-Chloro-4-iodobenzene → Allyl-{5-[1-(4-chloro-phenyl)-1H-indol-5-yl]-pentyl}-methyl-amine

HRID 1633684Notes

Reaction equation

HRID 1633684 reaction equation
[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH2:15][CH2:14]2)[CH3:5])[CH:2]=[CH2:3].[Cl:20][C:21]1[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=1>>[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:24]1[CH:25]=[CH:26][C:21]([Cl:20])=[CH:22][CH:23]=1)[CH:15]=[CH:14]2)[CH3:5])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 21966638Allyl-[5-(2,3-dihydro-1H-indol-5-yl)-pentyl]-methyl-amine

Product 1

HCID 10292379Allyl-{5-[1-(4-chloro-phenyl)-1H-indol-5-yl]-pentyl}-methyl-amine

Procedure

In analogy to example 12.7, Allyl-[5-(2,3-dihydro-1H-indol-5-yl)-pentyl]-methyl-amine and 1-chloro-4-iodobenzene were converted to yield Allyl-{5-[1-(4-chloro-phenyl)-1H-indol-5-yl]-pentyl}-methyl-amine as light brown semisolid, MS: 367(MH+, 1Cl).

Sources & evidence

ORD record
ord-87125f6cc01347958f6b802f4350e089
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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