1-Bromo-4-fluorobenzene → HCID 10159165, compound

HRID 1633689Notes

Reaction equation

HRID 1633689 reaction equation
[CH2:1]([N:4]([CH3:20])[CH2:5][CH2:6][CH2:7][C:8]#[C:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][CH:14]=[C:13]2[CH3:19])[CH:2]=[CH2:3].[Br:21][C:22]1[CH:27]=[CH:26][C:25](F)=[CH:24][CH:23]=1>>[CH2:1]([N:4]([CH2:5][CH2:6][CH2:7][C:8]#[C:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[N:15]([C:25]1[CH:26]=[CH:27][C:22]([Br:21])=[CH:23][CH:24]=1)[CH:14]=[C:13]2[CH3:19])[CH3:20])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 99931-Bromo-4-fluorobenzeneHCID 18679478HCID 18679478, compound

Product 1

HCID 10159165HCID 10159165, compound

Procedure

In analogy to example 9.1, Allyl-methyl-[5-(3-methyl-1H-indol-5-yl)-pent-4-ynyl]-amine and 1-bromo-4-fluorbenzene were converted to yield Allyl-{5-[1-(4-bromo-phenyl)-3-methyl-1H-indol-5-yl]-pent-4-ynyl}-methyl-amine as light yellow viscous oil, MS: 421 (MH+, 1Br).

Sources & evidence

ORD record
ord-404e0d2310d84d1f9d11b3e6ed6366a2
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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