1-Bromo-4-fluorobenzene → HCID 18679540, compound

HRID 1633692Notes

Reaction equation

HRID 1633692 reaction equation
[CH2:1]([N:4]([CH3:20])[CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]([CH3:19])=[CH:13]2)[CH:2]=[CH2:3].[Br:21][C:22]1[CH:27]=[CH:26][C:25](F)=[CH:24][CH:23]=1>>[CH2:1]([N:4]([CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[N:15]([C:25]1[CH:26]=[CH:27][C:22]([Br:21])=[CH:23][CH:24]=1)[C:14]([CH3:19])=[CH:13]2)[CH3:20])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 99931-Bromo-4-fluorobenzeneHCID 18679526HCID 18679526, compound

Product 1

HCID 18679540HCID 18679540, compound

Procedure

In analogy to example 9.1, Allyl-methyl-[4-(2-methyl-1H-indol-5-yloxy)-butyl]-amine and 1-bromo-4-fluorbenzene were converted to yield Allyl-{4-[1-(4-bromo-phenyl)-2-methyl-1H-indol-5-yloxy]-butyl}-methyl-amine as orange viscous oil, MS: 426 (M, 1Br).

Sources & evidence

ORD record
ord-fa79313b5b4d4ba1a83f552047168011
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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