1-Bromo-4-fluorobenzene → HCID 18679511, compound

HRID 1633696Notes

Reaction equation

HRID 1633696 reaction equation
[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15]([CH3:20])=[C:14]2[CH3:21])[CH3:5])[CH:2]=[CH2:3].F[C:23]1[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=1>>[CH2:1]([N:4]([CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:23]1[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][CH:24]=1)[C:15]([CH3:20])=[C:14]2[CH3:21])[CH3:5])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 99931-Bromo-4-fluorobenzeneHCID 18679574HCID 18679574, compound

Product 1

HCID 18679511HCID 18679511, compound

Procedure

In analogy to example 9.1, Allyl-[4-(2,3-dimethyl-1H-indol-5-yloxy)-butyl]-methyl-amine and 1-fluoro-4-bromobenzene were converted to yield Allyl-{4-[1-(4-bromo-phenyl)-2,3-dimethyl-1H-indol-5-yloxy]-butyl}-methyl-amine as orange oil, MS: 441 (MH+,1 Br).

Sources & evidence

ORD record
ord-b8b96a6626c24f6aaa61ba055c287bba
Source dataset
uspto-grants-2003_01
Patent number
US06503907B2

Reaction notes

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