HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 18679742, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | N,N-Dimethyl 4-iodo-1H-imidazole-1-sulfonamide | HCID 2773390 | — |
| Reactant | 6-Methoxy-5-nitro-1,2,3,4-tetrahydronaphthalen-1-one | HCID 13067337 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18679742 | HCID 18679742 | — |
Reaction Steps
A solution of 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (3.0 g, 10 mmol) (R. M. Turner, J. Org. Chem. (1991), 56, 5739-5740) in dichloromethane (40 mL) was treated with ethyl magnesium bromide (3.0M in diethyl ether, 3.3 mL) over 5 minutes, stirred for 30 minutes, treated with 6-methoxy-5-nitro-1-tetralone (2.6 g, 11.8 mmol), stirred for 16 hours, treated with ammonium chloride solution and extracted with dichloromethane. The extract was dried (MgSO4), filtered and concentrated to provide the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503935B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-ef094213dff74786b4547236844aa51b |
| Source note | uspto-grants-2003_01 |