Hydrochloric Acid → HCID 178504992, compound

HRID 1633717Notes

Reaction equation

HRID 1633717 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH2:8][CH2:9][CH2:10][CH:11]2[C:16]1[N:17]=[CH:18][N:19](C(OC(C)(C)C)=O)[CH:20]=1)(=[O:4])=[O:3].Cl>CO>[NH:19]1[CH:20]=[C:16]([C@@H:11]2[CH2:10][CH2:9][CH2:8][C:7]3[C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:15][CH:14]=[CH:13][C:12]2=3)[N:17]=[CH:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18679713HCID 18679713, compound

Product 1

HCID 178504992HCID 178504992, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Example 9B (130 mg, 0.33 mmol) in methanol (10 mL) was treated with 1N HCl (5 mL), stirred for 1.5 hours, concentrated at 45° C., and dried under vacuum for 30 minutes. The residue was dissolved in methanol, filtered through cotton, concentrated and dried under vacuum for 3 hours to provide the desired compound.

Workup

  1. concentrationconcentrated at 45° C.
  2. customdried under vacuum for 30 minutes
  3. dissolutionThe residue was dissolved in methanol
  4. filtrationfiltered through cotton
  5. concentrationconcentrated
  6. customdried under vacuum for 3 hours

Sources & evidence

ORD record
ord-bf8522a48c54468b9dd3de812335e895
Source dataset
uspto-grants-2003_01
Patent number
US06503935B1

Reaction notes

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