HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 11171569, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 5-Amino-3,4-dihydronaphthalen-1(2H)-one | HCID 11506505 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11171569 | HCID 11171569 | — |
Reaction Steps
A solution of 5-amino-1-tetralone (Itoh, K. Chem. Pharm. Bull. (1984), 32, 130-151) (0.50 g, 3.1 mmol) in dimethylformamide (15 mL) was treated with N-chlorosuccinimide (0.49 g, 3.7 mmol), stirred for 60 hours, treated with water and extracted with ether (4×30 mL). The combined ether extracts were washed with brine, dried (Na2SO4) and concentrated. Purification of the residue on silica gel with ethyl acetate:hexanes 1:1 provided the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06503935B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-40b217c9864946208015c6be2ef01444 |
| Source note | uspto-grants-2003_01 |