反应详情

A solution of 5-amino-1-tetralone (Itoh, K. Chem. Pharm. Bull. (1984), 32, 130-151) (0.50 g, 3.1 mmol) in dimethylformamide (15 mL) was treated with N-chlorosuccinimide (0.49 g, 3.7 mmol), stirred for 60 hours, treated with water and extracted with ether (4×30 mL). The combined ether extracts were washed with brine, dried (Na2SO4) and concentrated. Purification of the residue on silica gel with ethyl acetate:hexanes 1:1 provided the desired product.

1. extractionextracted with ether (4×30 mL)
2. washThe combined ether extracts were washed with brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. customPurification of the residue on silica gel with ethyl acetate:hexanes 1:1