Ethanesulfonyl chloride → HCID 18679802, compound

HRID 1633733Notes

Reaction equation

HRID 1633733 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([C:7]1[N:8]=[CH:9][N:10]([S:12]([N:15]([CH3:17])[CH3:16])(=[O:14])=[O:13])[CH:11]=1)=[O:6].[CH2:21]([S:23](Cl)(=[O:25])=[O:24])[CH3:22]>N1C=CC=CC=1>[CH2:21]([S:23]([NH:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5]([C:7]1[N:8]=[CH:9][N:10]([S:12]([N:15]([CH3:17])[CH3:16])(=[O:13])=[O:14])[CH:11]=1)=[O:6])(=[O:25])=[O:24])[CH3:22]

Participants

4

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 18679754HCID 18679754, compound

Product 1

HCID 18679802HCID 18679802, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of Example 55C in pyridine (30 mL) was treated with ethanesulfonyl chloride (0.11 mL, 11 mmol) at 0° C. The mixture was stirred at room temperature for the next 16 hours and then concentrated under vacuum. The residue was purified by column chromatography (silica gel, ethyl acetate)to provide 2.31 g (57%) of the title compound.

Workup

  1. concentrationconcentrated under vacuum
  2. customThe residue was purified by column chromatography (silica gel, ethyl acetate)

Sources & evidence

ORD record
ord-c5b2c025692c471db03fc015fb6ebfbe
Source dataset
uspto-grants-2003_01
Patent number
US06503935B1

Reaction notes

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