反应详情

According to the procedure of Preparation 4(b), except using tert-butyl 4-fluoro-3-methylbenzoate (6.25 g, 29.7 mmole), N-bromosuccinimide (5.75 g, 32.3 mmole), benzoyl peroxide (375 mg, 1 .6 mmole ), CCl4 (50 gL), and 2-phenethylamine (19 mL, 151 mmole ), the title compound (6.32 g, 64%) was prepared as a yellow oil following flash chromatography on silica gel (gradient: 20-40% EtOAc/hexanes): MS (ES) m/e 330.1 (M+H)+.