Trifluoroacetic acid → HCID 69561453, compound

HRID 1633878Notes

Reaction equation

HRID 1633878 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]=[CH:14][C:15]1[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=1)[CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)[CH:7]=[CH:6]2)#[N:2].C(O)(C(F)(F)F)=O>ClCCl>[CH2:21]1[C:22]2[C:17](=[CH:16][C:15]([CH:14]=[CH:13][C:8]3[CH:9]=[C:10]4[C:5](=[CH:6][CH:7]=3)[CH:4]=[C:3]([C:1]#[N:2])[CH:12]=[CH:11]4)=[CH:24][CH:23]=2)[CH2:18][CH2:19][NH:20]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69561113HCID 69561113, compound

Product 1

HCID 69561453HCID 69561453, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 42I (2.28 g, 0.55 mmol) in 1:1 dichloromethane:TFA (10 mL) at room temperature was stirred for 1 hour, then concentrated to provide the desired product.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-f58ecbd0cb5c45139256ca7456189286
Source dataset
uspto-grants-2003_01
Patent number
US06504031B1

Reaction notes

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