Acrylic Acid → N-(cyclopropylmethyl)-3-aminopropionic Acid

HRID 1633888Notes

Reaction equation

HRID 1633888 reaction equation
[C:1]([OH:5])(=[O:4])[CH:2]=[CH2:3].[CH:6]1([CH2:9][NH2:10])[CH2:8][CH2:7]1>CS(C)=O>[CH:6]1([CH2:9][NH:10][CH2:3][CH2:2][C:1]([OH:5])=[O:4])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 6581Acrylic AcidHCID 75646Cyclopropanemethanamine

Product 1

HCID 22502000N-(cyclopropylmethyl)-3-aminopropionic Acid

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The above resin bound acrylic acid (50 mg) was treated with 300 μmol cyclopropylmethyl amine (21.3 mg) in 300 μL DMSO for 72 hours at 25° C. The excess reagent was filtered off and the resin was washed with 3×1 mL DMSO and 3×1 mL DMF.

Workup

  1. filtrationThe excess reagent was filtered off
  2. washthe resin was washed with 3×1 mL DMSO and 3×1 mL DMF

Sources & evidence

ORD record
ord-5ead5eb1ed214f5585852a2a6430bbb4
Source dataset
uspto-grants-2003_01
Patent number
US06503949B1

Reaction notes

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