Diphosgene → HCID 22501838, compound

HRID 1633920Notes

Reaction equation

HRID 1633920 reaction equation
Cl.[CH2:2]([S:4][C:5]1[CH:6]=[C:7]([NH2:11])[CH:8]=[CH:9][CH:10]=1)[CH3:3].[O:12]=[C:13](Cl)OC(Cl)(Cl)Cl>C1(C)C=CC=CC=1>[CH2:2]([S:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N:11]=[C:13]=[O:12])[CH:6]=1)[CH3:3]

Participants

4

Reactant 2

HCID 10426DiphosgeneHCID 67484032HCID 67484032, compound

Product 1

HCID 22501838HCID 22501838, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a slurry of the above 3-ethylsulfanylphenylamine hydrochloride (31.6 mmol, 6 g) in toluene (100 mL) was added diphosgene (trichloromethyl chloroformate, 158 mmol, 31.3 g) and the mixture was refluxed for 2 hours affording a clear solution. The solvent was removed in vacuo and the residue was used without further purification.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. customaffording a clear solution
  3. customThe solvent was removed in vacuo
  4. customthe residue was used without further purification

Sources & evidence

ORD record
ord-632ce723f1cd4baea9d1b3f973782dfa
Source dataset
uspto-grants-2003_01
Patent number
US06503949B1

Reaction notes

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