HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminosalicylic Acid → Methyl Methacrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminosalicylic Acid | HCID 4075 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Methyl Methacrylate | HCID 6658 | — |
| Reactant | (+)-Lactose | HCID 440995 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl Methacrylate | HCID 6658 | — |
| Product | (2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;hydrate | HCID 66964417 | — |
Reaction Steps
5-Aminosalicylic acid (5-ASA), MgO for neutralization, and the additive were mixed in a mortar and made to prepare tablets. The tablets were coated with 11 wt % of a 10 w/v % methanol solution of Eudragit E100 by means of a Hicoater. Then tablets of lactulose were prepared and coated with 11 wt % of a 10 w/v % methanol solution of Eudragit RS100/triacetin (5/1). Each one of the tablets 1 and the tablets 2 and 200 mg of lactose were put in a #1 gelatin capsule. The capsule was coated first with a methanol dispersion of Eudragit RS100L/NaCl (particle size: 75 to 355 μm) (1/2) and then with 12 wt % of Eudragit L100/castor oil (5/1) to obtain the preparation of the present invention.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506407B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-9972061a223c42399be95ff3f04a58f3 |
| Source note | uspto-grants-2003_01 |