反应详情

温度

100 °C

Three point six five (3.65) grams (22.8 mmol) of diethyl malonate and 4.00 g (21.7 mmol) of 1,2-diphenylhydrazine were dissolved in 10 ml of n-butanol, then 4.61 g (23.9 mmol) of a 28% methanol solution of sodium methoxide was added thereto, and the reaction system was heated at 100° C. for 10 hours. Subsequently the solvent was distilled off under reduced pressure, 10 ml of water was added thereto and stirred, and then the reaction solution was filtered. An activated carbon was added to the recovered filtrate and stirred for 30 minutes. After stirring, the solution was filtered again to recover the filtrate. Four (4) ml of hydrochloric acid was added to the filtrate, and the precipitated solid was recovered by filtration. Thus, 3.76 g (yield: 60%) of 1,2-diphenyl-3,5-pyrazolidinedione was obtained.

1. distillationSubsequently the solvent was distilled off under reduced pressure, 10 ml of water
2. additionwas added
3. filtrationthe reaction solution was filtered
4. additionAn activated carbon was added to the recovered filtrate
5. stirringstirred for 30 minutes
6. stirringAfter stirring
7. filtrationthe solution was filtered again
8. customto recover the filtrate
9. additionFour (4) ml of hydrochloric acid was added to the filtrate
10. filtrationthe precipitated solid was recovered by filtration