HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl- | HCID 84657 | — |
Reaction Steps
2-fluoronitrobenzene was treated with aniline in the prescence of K2CO3 in CH3CN and heated to reflux for 12 h. The solution is cooled, filtered and the solvent removed. The nitro group is reduced with catalytic hydrogenation and the diamine treated with CDI to give 1-phenyl-1,3-dihydro-benzoimidazol-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506738B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-6ce79da2204742599c88902fe82d6331 |
| Source note | uspto-grants-2003_01 |