Benzyl isocyanate → HCID 70000528, compound

HRID 1634049Notes

Reaction equation

HRID 1634049 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][CH2:6][NH:7][C:8](=[O:23])[CH2:9][N:10]1[C:16](=[O:17])[C:15]2[CH:18]=[C:19]([NH2:22])[CH:20]=[CH:21][C:14]=2[O:13][CH2:12][CH2:11]1)[CH3:2].[CH2:25]([N:32]=[C:33]=[O:34])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][CH2:6][NH:7][C:8](=[O:23])[CH2:9][N:10]1[C:16](=[O:17])[C:15]2[CH:18]=[C:19]([NH:22][C:33]([NH:32][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[O:34])[CH:20]=[CH:21][C:14]=2[O:13][CH2:12][CH2:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 76639Benzyl isocyanateHCID 70001094HCID 70001094, compound

Product 1

HCID 70000528HCID 70000528, compound

Procedure

Treatment of 3-[2-(7-amino-5-oxo-2,3-dihydro-5H-benzo[f][1,4]oxazepin-4-yl)-acetylamino]-propionic acid ethyl ester (0.17 g, 0.5 mmol) with benzylisocyanate as described in Example 1 d) yielded 3-{2-[7-(3-benzyl-ureido)-5-oxo-2,3-dihydro-5H-benzo[f][1,4]oxazepin-4-yl]-acetylamino}-propionic acid ethyl ester (0.2 g, 0.42 mmol): mp. 70-75° C.; MS (ISP): 469 (M+1)+.

Workup

  1. customas described in Example 1 d

Sources & evidence

ORD record
ord-faf3736cf8f84e23a437846e327a31b5
Source dataset
uspto-grants-2003_01
Patent number
US06506744B1

Reaction notes

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