Ammonia → HCID 18677496, compound

HRID 1634209Notes

Reaction equation

HRID 1634209 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([NH2:10])[N:7]=[C:6]([NH2:11])[CH:5]=1.[NH3:13]>CO>[NH2:11][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([NH2:10])[N:7]=1)[C:3]([NH2:13])=[O:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 111945474-Pyridinecarboxylic acid, 2,6-diamino-, methyl ester

Product 1

HCID 18677496HCID 18677496, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
62 °C

Procedure

A solution of 3.9 g (20 mmol) 2,6-diamino-isonicotinic acid methyl ester in 200 ml methanol was treated for 1 at 0° C. with gaseous ammonia. The mixture was heated for 36 h at 62° C. in an autoclave (4 bar) and afterwards filtered through decalite and evaporated to dryness. 3.5 g (quant.) of the title compound was obtained as a yellow solid.

Workup

  1. filtrationafterwards filtered through decalite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-7a75bdbc53aa49ee9cb3ffb772f29118
Source dataset
uspto-grants-2003_01
Patent number
US06506772B1

Reaction notes

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