Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Pyridinecarboxylic acid, 2,6-diamino-, methyl ester | HCID 11194547 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 18677496 | HCID 18677496 | — |
Reaction Steps
A solution of 3.9 g (20 mmol) 2,6-diamino-isonicotinic acid methyl ester in 200 ml methanol was treated for 1 at 0° C. with gaseous ammonia. The mixture was heated for 36 h at 62° C. in an autoclave (4 bar) and afterwards filtered through decalite and evaporated to dryness. 3.5 g (quant.) of the title compound was obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06506772B1 |
|---|
| Source dataset | uspto-grants-2003_01 |
|---|
| ORD ID | ord-7a75bdbc53aa49ee9cb3ffb772f29118 |
|---|
| Source note | uspto-grants-2003_01 |
|---|
