HCID 23552469, compound → Acetonitrile--water (1/1)

HRID 1634217Notes

Reaction equation

HRID 1634217 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:14]=[C:15]([NH:17]C(=O)C)[N:16]=1)[C:8](N(OC)C)=[O:9])(=[O:3])[CH3:2].[C:21]1([Mg]Br)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[NH2:17][C:15]1[CH:14]=[C:7]([C:8]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:9])[CH:6]=[C:5]([NH2:4])[N:16]=1.[C:1](#[N:4])[CH3:2].[OH2:3]

Participants

4

Reactant 2

HCID 23552469HCID 23552469, compoundHCID 178418255HCID 178418255, compound

Product 2

HCID 18373917Acetonitrile--water (1/1)Yield 37%HCID 18677493HCID 18677493, compound

Procedure

The title compound was prepared in accordance with the general method of example 371 from 2,6-bis-acetylamino-N-methoxy-N-methyl-isonicotinamide and phenylmagnesium bromide. The purification was performed by reversed phase HPLC eluting with an acetonitrile/water gradient Yield: 37%.

Workup

  1. customThe purification

Sources & evidence

ORD record
ord-a78f7aa07087417ab98538e1221d1140
Source dataset
uspto-grants-2003_01
Patent number
US06506772B1

Reaction notes

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