8-Amino-4,4-dimethyl-2h,4h-isoquinoline-1,3-dione → 4,4-dimethyl-7-acetamino-2H,4H-isoquinoline-1,3-dione

HRID 1634222Notes

Reaction equation

HRID 1634222 reaction equation
N[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:10](=[O:12])[NH:9][C:8](=[O:13])[C:7]2([CH3:15])[CH3:14]>C(OC(=O)C)(=O)C>[C:10]([NH:9][C:3]1[CH:2]=[C:11]2[C:6]([C:7]([CH3:15])([CH3:14])[C:8](=[O:13])[NH:9][C:10]2=[O:12])=[CH:5][CH:4]=1)(=[O:12])[CH3:11]

Participants

3

Reactant 1

HCID 235029148-Amino-4,4-dimethyl-2h,4h-isoquinoline-1,3-dione

Product 1

HCID 135581564,4-dimethyl-7-acetamino-2H,4H-isoquinoline-1,3-dioneYield 171.3%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

The above amine (1.5 g, 7.35 mmol) was stirred in acetic anhydride (9 mL) at room temperature for 3 h, then poured on to ice. The precipitate was filtered, washed with water and dried to give 7-acetamido-4,4-dimethyl-2H,4H-isoquinoline-1,3-dione (1.55 g, 86%)

Workup

  1. additionpoured on to ice
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-7117a601929b4bd384c4a312cbb6b153
Source dataset
uspto-grants-2003_01
Patent number
US06506769B2

Reaction notes

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