Hydroxyamine hydrochloride → HCID 87971557, compound

HRID 1634292Notes

Reaction equation

HRID 1634292 reaction equation
[Br:1][C:2]1[C:7]2[CH:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:9][C:10]3[C:15]([C:6]=2[CH:5]=[CH:4][C:3]=1[C:24](=O)[CH3:25])=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][CH:11]=3.Cl.[NH2:28][OH:29]>CCO.N1C=CC=CC=1>[Br:1][C:2]1[C:7]2[CH:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:9][C:10]3[C:15]([C:6]=2[CH:5]=[CH:4][C:3]=1[C:24](=[N:28][OH:29])[CH3:25])=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][CH:11]=3

Participants

5

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 22314897HCID 22314897, compound

Product 1

HCID 87971557HCID 87971557, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1049PyridineSolvent

Procedure

A solution of Example 357C (700 mg, 2.03 mmol) and hydroxylamine hydrochloride (2.45 g, 30.4 mmol) in a mixture of EtOH (70 mL) and pyridine (70 mL) was refluxed for 8 hours, cooled and concentrated. The residue was dissolved in EtOAc, washed with water, brine, dried (Na2SO4) and concentrated to provide the desired compound without purifiction.

Workup

  1. temperaturewas refluxed for 8 hours
  2. temperaturecooled
  3. concentrationconcentrated
  4. dissolutionThe residue was dissolved in EtOAc
  5. washwashed with water, brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-061e0552205a42518d24f998ffc066f3
Source dataset
uspto-grants-2003_01
Patent number
US06506766B1

Reaction notes

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